Each tablet contains:
Composition:
Nimesulide.............................................................100
mg
Indications :
Nimesulide is indicated in the
treatment of a variety of
painful inflammatory conditions
including those associated with
osteoarthritis, postoperative
trauma, sports injuries, acute
musculoskeletal disorders
including tendonitis,
tenosynovitis, sprains, strains
and low back pain, ear, nose and
throat disorders, dental
surgery, bursitis/tendonitis,
thrombophlebitis, pharyngitis
and gynaecological disorders.
Description:
Nimesulide is a nonsteroidal
anti-inflammatory drug (NSAID)
of the sulfonanilide class. Its
anti-inflammatory, analgesic and
antipyretic activities have been
demonstrated in several widely
used animal experimental models
and in numerous clinical trials.
Nimesulide only weakly inhibits
prostaglandin synthesis and
appears to exert its effects
through various mechanisms. It
inhibits the release of oxidants
from activated neutrophils and
has a scavenging effect on
hypochlorous acid without
affecting neutrophil function.
Nimesulide also decreases
histamine release from tissue
mast cells and inhibits the
production of
platelet-activating factor by
human basophils. Furthermore,
when added in vitro to cultures
of human articular chondrocytes,
nimesulide inhibits the release
of stromelysin and blocks
metalloproteinase activity.
Contraindications:
Active peptic ulcer disease.
Moderate to severe hepatic
impairment. n patients who have
previously shown a
hypersensitivity to it or
nimesulide in any of its dosage
forms.
Dosage:
Usual oral dose of Nimesulide in
adults is 100 mg twice daily.
Presentations:
10 tablets
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22.00 17.60
15.84
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