as part of combination therapy is indicated for the
treatment of HIV infection when antiretroviral therapy
is warranted. Maternal-Fetal HIV Transmission:
Zedvin-Cis also indicated for the prevention of
maternal-fetal HIV transmission. The safety of
zidovudine for the mother or foetus during the first
trimester of pregnancy has not been assessed.
Zidovudine is a member of a class of compounds called
dideoxynucleosides. It is a thymidine analog in which
the 3'-hydroxyl -OH) group is replaced by an azido
(-N[.sub.3]) group. The chemical name of zidovudine is
The drug has a limited spectrum of antiviral activity.
It is active against human retroviruses, including HIV
type 1 (HIV-1), HIV type 2 (HIV-2) and human T-cell
lymphotropic virus type 1 (HTLV-1). It is also active
against many animal retroviruses, such as feline
leukemia virus, Friend murine leukemia virus, Harvey
murine sarcoma virus and simian T-lymphotropic virus
Zidovudine is active in vitro against many
Enterobacteriaceae, but resistance develops rapidly. The
drug has no activity against grampositive organisms,
anaerobes, mycobacteria or fungi.
The drug is contraindicated for patients who have
potentially life-threatening allergic reactions to any
of the components of the formulations.
per the physician’s advice.