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Therapeutic Index

TRIP-MAX

Each kit contains:

Composition:

1 cap of Rifampicin.............................................450 mg

1 Tab of  Ethambutol............................................800 mg

1 Tab of  INH..........................................................150 mg

2 Tab of  Pyrazinamide.........................................750 mg

 

Indications:

Rifampicin, Ethambutol, Isoniazid, Pyrazinamide and Streptomycin are  used in medication and management of Tuberculosis.

 
Description:
Rifampicin inhibits DNA-dependent RNA polymerase in bacterial cells by binding its beta subunit, thus preventing transcription of messenger RNA (mRNA) and subsequent translation to proteins.
Ethambutol is a synthetic, bacteriostatic antitubercular agent. Ethambutol diffuses into actively growing mycobacteria cells such as tubercle bacilli . It appears to inhibit the synthesis of one or more metabolites, thus impairing cell metabolism, arresting multiplication, and resulting in cell death.
INH is thought to work through its effects on lipids (fats) and DNA within the tuberculosis bacterium.
Pyrazinamide is a prodrug that stops the growth of Mycobacterium tuberculosis. M. tuberculosis has the enzyme pyrazinamidase which is only active at acidic pH. Pyrazinamidase converts pyrazinamide to the active form, pyrazinoic acid. Pyrazinoic acid inhibits the enzyme fatty acid synthetase I, which is required by the bacterium to synthesise fatty acids.

Dosage:

Adults: (below 50 kg): 450 mg daily as a single dose. More than 50 kg: upto 600 mg daily.

Children: 10-15 mg /kg body wt. daily as single dose.

Presentations:         1 kit
                                     MRP               Retailer            Stockiest
              
                                    14.10                11.28                   10.15

 
 

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