|
Compositions:
Mixture of various juices.
Indications:
Soft Drink
Descriptions:
Taj
mugal-e-ajam sharbat is a combination of Mixture of
various juices.
Drugs that
interact with grapefruit and/or grapefruit juice (GJ)
undergo cytochrome p450 oxidative metabolism in the
intestinal wall or liver. GJ contains various
furanocoumarins which have been demonstrated to affect
the cytochrome p450 (CYP) system (especially at
isoenzyme CYP3A4) by binding to the isoenzyme as a
substrate and impairing first-pass metabolism, by direct
inactivation or inhibition of the enzyme
(mechanism-based inhibitors). The net effect on the CYP
enzymes from this inhibition seems to be a selective
down-regulation of CYP3A4 in the small intestine. For
certain drugs which are known to be CYP 3A4 metabolized,
less drug is metabolized prior to absorption, and
greater amounts of these drugs reach the systemic
circulation, leading to higher blood levels, and
potentially to increases in therapeutic and/or toxic
effects.
Presentations:
MRP Retailer
Stockist
500 ml
60.00
48.00
43.20
750 ml
84.00
67.20
60.48 | 
