film coated tablet contains :
Bupropion hydrochloride 150 mg (As
Nicotoxin is indicated for the treatment of depression.
It is also indicated as a smoking cessation treatment.
Bupropion is a norepinephrine and dopamine uptake
inhibitor that has been available for several years for
the treatment of depression and aiding smokers to quit.
Bupropion is an antidepressant medication that affects
chemicals within the brain that nerves use to send
messages to each other. These chemical messengers are
called neurotransmitters. The neurotransmitters that are
released by nerves are taken up again by the nerves that
release them for reuse. (This is referred to as
reuptake.) Many experts believe that depression is
partly caused by an imbalance among the amounts of
neurotransmitters that are released. Bupropion is
unrelated to other antidepressants. It works by
inhibiting the reuptake of dopamine, serotonin, and
norepinephrine, an action which results in more
dopamine, serotonin, and norepinephrine to transmit
messages to other nerves. Bupropion is unique in that
its major effect is on dopamine, an effect which is not
shared by the selective serotonin reuptake inhibitors or
SSRIs (e.g. paroxetine, Paxil; fluoxetine, Prozac;
sertraline, Zoloft) or the tricyclic antidepressants or
TCAs (e.g. amitriptyline, Elavil; imipramine, Tofranil;
desipramine, Norpramin). Bupropion hcl is available as
sustained release bupropion SR.
Adults: Initially, 150 mg once daily in the morning;
titrate after no less than 4 days to 150 mg twice daily
if needed. The onset of antidepressant effects takes 1–3
weeks, maximal effect may not be noted for 4 weeks. The
lowest dosage that maintains remission is recommended.