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Therapeutic Index

NAMOSID

Each tablet contains:

 

Composition:

Nimesulide.............................................................100 mg

 

Indications :

Nimesulide is indicated in the treatment of a variety of painful inflammatory conditions including those associated with osteoarthritis, postoperative trauma, sports injuries, acute musculoskeletal disorders including tendonitis, tenosynovitis, sprains, strains and low back pain, ear, nose and throat disorders, dental surgery, bursitis/tendonitis, thrombophlebitis, pharyngitis and gynaecological disorders.

 

Description:

Nimesulide is a nonsteroidal anti-inflammatory drug (NSAID) of the sulfonanilide class. Its anti-inflammatory, analgesic and antipyretic activities have been demonstrated in several widely used animal experimental models and in numerous clinical trials. Nimesulide only weakly inhibits prostaglandin synthesis and appears to exert its effects through various mechanisms. It inhibits the release of oxidants from activated neutrophils and has a scavenging effect on hypochlorous acid without affecting neutrophil function. Nimesulide also decreases histamine release from tissue mast cells and inhibits the production of platelet-activating factor by human basophils. Furthermore, when added in vitro to cultures of human articular chondrocytes, nimesulide inhibits the release of stromelysin and blocks metalloproteinase activity.

 

Contraindications:

Active peptic ulcer disease. Moderate to severe hepatic impairment. n patients who have previously shown a hypersensitivity to it or nimesulide in any of its dosage forms.

 

Dosage:

Usual oral dose of Nimesulide in adults is 100 mg twice daily.

Presentations:    10 tablets             
                                   
MRP         Retailer        Stockist
                                  
22.00          17.60             15.84

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