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Each
uncoated tablet contains:
Composition:
Misoprostol......................................................................100
mcg
Excipients..................................................................................q.s.
Approved colours used
Indications:
Treatment of duodenal, gastric and NSAID induced ulceration.
Misobortol should be taken for the duration of NSAID
therapy.
Description:
Misoprostol is a synthetic analogue of naturally
occurring prostaglandin E1. It has been approved in more
than 90 countries for prevention and treatment of
gastric and duodenal ulcers. Very few countries have
misoprostol registered as an abortion pill. It is safe
and well tolerated, and can be kept at room temperature
when packed in aluminium blisters.
Outcome of treatment with misoprostol when used
orally or vaginally has shown a complete abortion rate
of 87% and 95%, incomplete abortion 3% and 4%, missed
abortion 3% and 1% and continuing pregnancy in 7% and 1%
respectively.
Misoprostol is rapidly absorbed after oral
administration and converted to its pharmacologically
active metabolite, misoprostol acid. Plasma
concentrations of misoprostol acid peak in approximately
30 minutes and decline rapidly thereafter.
The effects of misoprostol on the reproductive
tract are increased, and gastrointestinal adverse
effects are decreased, if this is administered
vaginally. On vaginal administration, the plasma
concentrations of misoprostol acid peaks in 1-2 hours
and then declines slowly. Vaginal application results in
slower increase and lower peak plasma concentration of
misoprostol acid than does oral administration. Uterine
contractility increases and then plateaus one hour after
oral administration, whereas, contractility continues
for four hours after vaginal route.
Dosage :
The recommended adult oral dose for the treatment of
duodenal, gastric and NSAID induced ulceration is 200
mcg 4 times daily with food and at bedtime for 4-8
weeks.
If this dose is not tolerated, a dose of 100 mcg can be
used.
Presentations :
4
tablets
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