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Therapeutic Index

MEROPEN

Each 1ml contains :

 

Composition:

Meropenem ......................................................................1 g

Meropenem ..................................................................500 mg

 

Indications :

Intra-abdominal infections, nosocominal pneumonia, septicaemia, cystic fibrosis, meningitis, febrile neutropenia.

 

   Description:

The bactericidal activity of meropenem results from the inhibition of cell wall synthesis. Meropenem readily penetrates the cell wall of most Gram-positive and Gram-negative bacteria to reach penicillin-binding- protein (PBP) targets. Its strongest affinities are toward PBPs 2, 3 and 4 of Escherichia coli and Pseudomonas aeruginosa; and PBPs 1, 2 and 4 of Staphylococcus aureus.

Dosage : Intra-abdominal infections; nosocominal pneumonia; septicaemia:  Adults: 500mg-1g hrly depending on the severity and type. IV infusion, over approx. 15 to 30 minutes or as an intravenous bolus injection (5 to 20 mL) over approximately 3-5minutes.  Child: (3 months to 12 yrs): IV 10 to 40mg/kg 8hrly, or as reqd.  Cystic fibrosis; meningitis: Adults: 2g 8 hrly.  Febrile neutropenia: 1g 8 hrly.

Presentations:                         Vial 1 ml
                                          MRP            Retailer          Stockiest
                                       1960.50        1568.40            1411.56

 
 

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