T
Taj For DoctorsTaj Doctor
home

About Us

Taj Brands

Diseases Health Tips  HIV/AIDS News Contact Us

 

  All News
  Allergy
  Asthma
  Cardiology
  Clinical Research
  Critical Care
  Dentistry
  Dermatology
  Endocrinology
  Gastroenterology
  General
  Genetics / Biotech
  Men's Health
  Infectious Diseases
  Fitness/Lifestyle
  Nephrology
  Neurology
  Oncology/Haematology
  Ophthalmology
  Orthopaedics
  Otolaryngology
  Paediatrics
  Psychiatry
  Reproductive Health
  Respiratory Medicine
  Surgery
  Sex
  Urology
  Women's Health
Taj Brands


Therapeutic Index

LOBIVIR

Each film-coated tablet contains :

Composition:

Lamivudine           .....................................................................100 mg

 

Indications :

Lobivir HBV is indicated for the treatment of chronic Hepatitis B and evidence of hepatitis B virus (HBV) replication in patients with decompensated liver disease or active inflammation and/or fibrosis.

 

Description:

Lamivudine (ß-L-2',3'-dideoxy-3'-thiacytidine), one of the dideoxycytidine (ddC) analogue NRTIs, is the first nucleoside analogue approved to treat chronic HBV infection and has been shown to benefit various categories of patients. These include HBe-positive and -negative patients, non-responders to interferon-{alpha} therapy, and patients with decompensated cirrhosis.

Lamivudine’s D-isomer is less active against HBV replication and more cytotoxic than the L-isomer. Both the D- and L-isomers of 2',3'-dideoxy- 3'-thiauridine were found to be inactive against HBV replication, and the susceptibility of the thiacytidine stereoisomers to cytidine and/or deoxycytidine deaminase was suspected to be the reason. In fact, the racemic mixture and the D-isomer of 2',3'-dideoxy-3'-thiacytidine were deaminated with partially purified human deaminase and were found to be processed to the

D-isomer of the thiauridine, while lamivudine and ddC were not. Despite the intracellular stability of its cytosine base, ddC was less effective than lamivudine in a cell culture system. Until recently, it was thought that the potency of lamivudine reflected the higher incorporation efficiency into newly synthesized DNA by the viral DNA polymerase. Lamivudine and ddC are phosphorylated to their triphosphates and then the triphosphates act as chain terminators during viral and cellular DNA synthesis.

 

CONTRA-INDICATIONS:

EPIVIR Tablets and Oral Solution are contraindicated in patients with previously demonstrated clinically significant hypersensitivity to any of the components of the products.

 

Dosage: The recommended dosage of Lobivir HBV is 100 mg once daily or as per the physician’s advice.

Presentations:                10 tablets        
                                                
MRP          Retailer         Stockiest
                                              
820.00         656.00            590.40

 
 

         Copyright © 2004- 2006 TAJ Pharmaceuticals Limited. All Rights Reserved.

Site Requirements : Internet Explorer 5.0+ or Netscape 5.0+, Flash Player 5.0 & Real Player 8 Basic
To get in touch with us, call on 91-22-2637 4592, 91--22-2637 4593 or fax us at 91-22-2634 1274 

Terms and Conditions | Disclaimer | Privacy Policy | Sitemap | Feedback | FAQ