Mild to moderate Hypertension
Frusemide can inhibit various indirectly acting
bronchoconstrictor stimuli in asthmatic patients.
Frusemide also modulate airway neurotransmission in some
species but there are no data on the effect
of loop diuretics on neurotransmission in man.The
mechanism of action of frusemide on airway
nerves remains unclear: inhibition of the Na-K-Cl
cotransporter is a possibility and, for
frusemide, release of endogenous cyclooxygenase
products may be involved. Carbonic anhydrase
inhibition, on the other hand, is unlikely to
be a factor.
This study has provided evidence to support the hypothesis
that frusemide inhibit sensory nerve activation to
reduce the itch and flare responses induced by histamine
in human skin in vivo. It is likely that inhibition of a
Na [+]/K [+]/2Cl [-] cotransporter in the sensory nerve
membrane is a possible mechanism of action.
The use of frusemide led to symptomatic improvement
shortly after its administration. They proposed that a 'diuresis'
was occurring through the skin, as their patients did
not exhibit increased urine output before the
improvement was noted, but instead seemed to sweat
excessively. The effect of frusemide on veins has been
shown to be mostly an indirect one, but frusemide may
also display direct venodilator properties.
Mild to moderate Hypertension:
40-80 mg once or twice daily. Cardiac, pulmonary, renal,
hepatic and cerebral oedema: 20-80 mg as a single dose
daily or on alternate days. Children: 1-2 mg/kg/day as
Severe sodium and water
depletion, hypersensitivity to sulphonamides and
frusemide, hypokalaemia, hyponatraemia, precomatose
states associated with liver cirrhosis, Addison’s
MRP Retailer Stockist
3.80 3.04 2.73