T
Taj For DoctorsTaj Doctor
home

About Us

Taj Brands

Diseases Health Tips  HIV/AIDS News Contact Us

 

  All News
  Allergy
  Asthma
  Cardiology
  Clinical Research
  Critical Care
  Dentistry
  Dermatology
  Endocrinology
  Gastroenterology
  General
  Genetics / Biotech
  Men's Health
  Infectious Diseases
  Fitness/Lifestyle
  Nephrology
  Neurology
  Oncology/Haematology
  Ophthalmology
  Orthopaedics
  Otolaryngology
  Paediatrics
  Psychiatry
  Reproductive Health
  Respiratory Medicine
  Surgery
  Sex
  Urology
  Women's Health
Taj Brands


Therapeutic Index

ENBROL INJ

Each 1 ml contains:

 

Composition:

Etanercept .......................................................................25 mg

 

Indications:

For reducing signs and symptoms and inhibiting the progress of structural damage in patients with moderately to severely active rheumatoid arthritis. In combination with methotrexate in patients who do not respond to methotrexate alone. To reduce symptoms and signs of moderately to severely active poly-articular-course juvenile rheumatoid arthritis (JRA) in patients who have had an inadequate response to one or more DMARDs.

 

Description:

Etanercept inhibits TNF activity by competitively binding to it and preventing interactions with its cell surface receptors. Elevated levels of TNF have been found in psoriatic skin lesions, and in synovial explants and fluid from patients with psoriatic arthritis.[5-7] Furthermore, TNF levels in the serum of patients with plaque psoriasis, and in blister fluids of involved psoriatic skin[9] have also been shown to be higher than in those of controls. These values were significantly correlated with the psoriasis area and severity index (PASI) scores, and TNF levels were reduced in association with clinical resolution after effective treatment.

The production of chemokines, and the expression of adhesion molecules by keratinocytes and vascular endothelial cells can be stimulated by TNF produced within psoriatic lesions. These signals then cause recruitment of additional inflammatory cells into the plaque. Krueger suggests that TNF may function as part of a positive feedback loop, which acts to amplify and sustain the inflammatory process within psoriatic plaques.[10] Biologic responses that are induced or regulated by TNF are modulated by etanercept. It may, therefore, serve to reduce inflammation within plaques by breaking this cycle.

    Dosage:

Adults: 25mg given twice weekly as a subcutaneous injection 72-96 hours apart. Methotrexate, glucocorticoids, NSAIDs, or analgesics may be continued during treatment with etanercept.  JRA patients: For paediatric patients (4 to 17 years), dose is 0.4mg/kg (up to a maximum of 25mg per dose) given twice weekly as a subcutaneous injection 72-96 hours apart. Glucocorticoids, NSAIDs, or analgesics may be continued during treatment with etanercept.

Presentations:       Vial 1 ml              
                                      MRP       Retailer        Stockiest
                                 
9055.60    7244.00          6519.60

 
 

         Copyright 2004- 2006 TAJ Pharmaceuticals Limited. All Rights Reserved.

Site Requirements : Internet Explorer 5.0+ or Netscape 5.0+, Flash Player 5.0 & Real Player 8 Basic
To get in touch with us, call on 91-22-2637 4592, 91--22-2637 4593 or fax us at 91-22-2634 1274 

Terms and Conditions | Disclaimer | Privacy Policy | Sitemap | Feedback | FAQ