Each tablet contains
Dothiepin hydrochloride 5mg
Depression. Anxiety associated with depression.
Adults: Initially 75mg daily in divided doses or as
a single dose at night. Increasing to 150 mg with
caution & under close supervision. Maintanence: 150
mg as a single dose at night. Children: Not
Anticholinergics: Enhanced effect of
anticholinergics may occur. Barbiturates: Serum
level of imipramine decreased; additive respiratory
depressant effect. Clonidine: Hypertensive crisis.
Dicoumarol: Increase in anticoagulation effects.
Disulfiram: Acute organic brain syndrome. Fluoxetine
& Haloperidol: Potentiate action of imipramine.
Levodopa: Its bioavailability is reduced,
hypertensive episodes. MAOIs, Furazolidone:
Seizures, sweating, coma, hyperexcitability,
hyperthermia, tachycardia, mydriasis, confusion, DIC.
(Disseminated Intravascular Coagulation) and death.
Oral Contraceptives and Phenothiazines: Increase
plasma levels of imipramine. Smoking: Increases
metabolic bio-transformation. Alcohol: Sedative
effect of alcohol potentiated.
Should be take by on the prescription of a
registered medical practitioner only.
Blister pack of 30 tablets