Each film-coated tablet contains
Clithrocin is indicated for the treatment of mild to
moderate infections due to susceptible organisms.
Upper respiratory tract infections Pharyngitis,
tonsillitis. Lower respiratory tract infections
Acute and chronic bronchitis, pneumonia
Uncomplicated skin and skin structure infections
like Folliculitis, Cellulitis, Erysipelas.
Clarithromycin, a macrolide antibiotic similar to
erythromycin and azithromycin, is effective against
Mycobacterium avium complex (MAC) and is used for
the treatment of Helicobacter pylori-associated
peptic ulcer disease, community-acquired pneumonia,
sinusitis, and chronic bronchitis. Clarithromycin is
also used to treat respiratory tract, sexually
transmitted, otitis media, and AIDS-related
infections. For the treatment of Bacterial infection
of (Pharyngitis/Tonsillitis, sinusitis, bronchitis,
Pneumonia, Uncomplicated skin and skin structure
infections ) caused by H.influenzae, M.catarrhalis,
M.pneumoniae, S.pneumoniae, C.pneumoniae (TWAR),
Clarithromycin is first metabolized to 14-OH clarithromycin.
Like other macrolides, it then binds to the 50 S
subunit of the 70 S ribosome of the bacteria,
blocking RNA-mediated bacterial protein synthesis.
Clarithromycin also inhibits the hepatic microsomal
CYP3A4 isoenzyme and P-glycoprotein, an
energy-dependent drug efflux pump.
Clarithromycin is contraindicated in patients with a known
hypersensitivity to clarithromycin, erythromycin, or
any of the macrolide antibiotics. Concomitant
administration of clarithromycin with cisapride,
pimozide, or terfenadine is contraindicated. There
have been post-marketing reports of drug
interactions when clarithromycin and/or erythromycin
are co-administered with cisapride, pimozide, or
terfenadine resulting in cardiac arrhythmias (QT
prolongation, ventricular tachycardia, ventricular
fibrillation, and torsades de pointes) most likely
due to inhibition of hepatic metabolism of these
drugs by erythromycin and clarithromycin.
Adults: Children > 12 years:
The usual dose is one tablet (250 mg) twice daily for 7 days,
although this may be increased to two tablets (500
mg) twice daily for up to 14 days in severe
Children less than 12 years: 7.5 mg/kg every 12
hours for 10 days.