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Each 2ml contains:
Composition:
β
Arteether
………….........................................……150 mg
Arachis
Oil I.P.
.............................................................q.s.
Indications :
Artemotial is concentrated in parasitized erythrocytes.
The functional group responsible for anti-malarial
activity of α / β arteether is endoperoxide bridge. Iron
from the digested haemoglobin of the parasite's victim
reduces this bridge, releasing a highly reactive free
radical iron species which causes lysis of the parasitic
cell.
Description:
β arteether is a fast
acting blood schizonticidal agent for P. falciparum
malaria at the erythrocytic stage.
β arteether is concentrated in parasitized erythrocytes.
The functional group responsible for antimalarial
activity of β arteether is endoperoxide bridge. Iron
from the digested haemoglobin of the parasite's victim
reduces this bridge, releasing a highly reactive free
radical iron species which causes lysis of the parasitic
cell.
Lysis of parasitic cell membrane occurs. Damage includes
swelling and deformity of food vacuoles membrane,
nuclear membrane, endoplasmic reticulum and formation of
autophagic vacuoles.
It is also proposed that β arteether inhibits the
protein synthesis and alters the ribosomal organization
and endoplasmic reticulum.
CONTRAINDICATIONS
β
arteether injection is contraindicated in patients
hypersensitive to artemisinin derivatives
Dosage:
Adult: 150mg i.e. 1 ampoule of b arteether once daily
for 3 consecutive days.
Children: 3mg/Kg per day administered by intramuscular
injection over a 3-day period.
Presentations:
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