|
Each
Injection contians:
Composition:
Melphalan
.........................................................50
mg
Indications:
Breast
carcinoma, multiple myeloma, advanced ovarian carcinoma,
other neoplasms in combination with surgery. Malignant
melanoma, polycythaemia vera.
Description:
Melphalan also known as L-phenylalanine mustard,
phenylalanine mustard, L-PAM or L-sarcolysin, is a
phenylalanine derivative of nitrogen mustard. Melphalan
is a bifunctional alkylating agent which is active
against selective human neoplastic diseases. It is known
chemically as 4-[bis(2-chloroethyl)
amino]-L-phenylalanine. The molecular formula is
C13H18Cl2N2O2 and the molecular weight is 305.20.
Melphalan is the active L-isomer of the compound and was
first synthesized in 1953 by Bergel and Stock; the D
isomer, known as medphalan, is less active against
certain animal tumors, and the dose needed to produce
effects on chromosomes is larger than that required with
the L-isomer.
CONTRAINDICATIONS
ALPHEN
should not be used in patients whose disease has
demonstrated a prior resistance to this agent. Patients
who have demonstrated hypersensitivity to melphalan
should not be given the drug.
Dosage :
Adults:
Multiple myeloma: Usual oral dose 6mg/day. Maintenance
dose 2mg/day.
Children: Multiple myeloma: 0.15mg/kg/day for 7 days.
Maintenance dose 0.05mg/kg/day when WBC/platelets count
are rising. Ovarian carcinoma: 0.2mg/kg/day for 5 days.
Repeat course after 4-5 weeks.
Presentations:
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