carcinoma, multiple myeloma, advanced ovarian carcinoma,
other neoplasms in combination with surgery. Malignant
melanoma, polycythaemia vera.
Melphalan also known as L-phenylalanine mustard,
phenylalanine mustard, L-PAM or L-sarcolysin, is a
phenylalanine derivative of nitrogen mustard. Melphalan
is a bifunctional alkylating agent which is active
against selective human neoplastic diseases. It is known
chemically as 4-[bis(2-chloroethyl)
amino]-L-phenylalanine. The molecular formula is
C13H18Cl2N2O2 and the molecular weight is 305.20.
Melphalan is the active L-isomer of the compound and was
first synthesized in 1953 by Bergel and Stock; the D
isomer, known as medphalan, is less active against
certain animal tumors, and the dose needed to produce
effects on chromosomes is larger than that required with
should not be used in patients whose disease has
demonstrated a prior resistance to this agent. Patients
who have demonstrated hypersensitivity to melphalan
should not be given the drug.
Multiple myeloma: Usual oral dose 6mg/day. Maintenance
Children: Multiple myeloma: 0.15mg/kg/day for 7 days.
Maintenance dose 0.05mg/kg/day when WBC/platelets count
are rising. Ovarian carcinoma: 0.2mg/kg/day for 5 days.
Repeat course after 4-5 weeks.