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Composition:
Each capsule contains:
Zidovudine USP
................................................................100
mg
Indications :
Zedvin-C as part of combination therapy
is indicated for the treatment of HIV
infection when antiretroviral therapy is
warranted. Maternal-Fetal HIV
Transmission:
Zedvin-Cis also indicated for the
prevention of maternal-fetal HIV
transmission. The safety of zidovudine
for the mother or foetus during the
first trimester of pregnancy has not
been assessed.
Description:
Zidovudine is a member of a class of
compounds called dideoxynucleosides. It
is a thymidine analog in which the
3'-hydroxyl -OH) group is replaced by an
azido (-N[.sub.3]) group. The chemical
name of zidovudine is
3'-azido-3'-deoxythymidine.
The drug has a limited spectrum of
antiviral activity. It is active against
human retroviruses, including HIV type 1
(HIV-1), HIV type 2 (HIV-2) and human
T-cell lymphotropic virus type 1
(HTLV-1). It is also active against many
animal retroviruses, such as feline
leukemia virus, Friend murine leukemia
virus, Harvey murine sarcoma virus and
simian T-lymphotropic virus type 3.
Zidovudine is active in vitro against
many Enterobacteriaceae, but resistance
develops rapidly. The drug has no
activity against grampositive organisms,
anaerobes, mycobacteria or fungi.
CONTRAINDICATIONS
The drug is contraindicated for patients who have
potentially life-threatening allergic
reactions to any of the components of
the formulations.
Dosage: As
per the physician’s advice.
Presentations: 10 caps.
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