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Therapeutic Index

ZENTIC-400

Each tablet contains:


Composition:

Albendazole....................................................................400 mg

 

Indications :

ZENTIC-400  is indicated in the treatment of hookworm (ancyclostoma, necator), roundworm (ascaris), threadworm (strongyloides), whipworm (trichuris), tapeworm (taenia species), opisthorchis, hydatid disease (echinococcus),neurocysticercosis, mixed helminthic infestations.

 

Description:

Albendazole causes degenerative alterations in the tegument and intestinal cells of the worm by binding to the colchicine-sensitive site of tubulin, thus inhibiting its polymerization or assembly into microtubules. The loss of the cytoplasmic microtubules leads to impaired uptake of glucose by the larval and adult stages of the susceptible parasites, and depletes their glycogen stores. Degenerative changes in the endoplasmic reticulum, the mitochondria of the germinal layer, and the subsequent release of lysosomes result in decreased production of adenosine triphosphate (ATP), which is the energy required for the survival of the helminth. Due to diminished energy production, the parasite is immobilized and eventually dies.

 

Dosage : Adults and children over two years: 1 tablet or 10 ml suspension (400 mg) as a single dose. In strongyloides or H. nana infestations, 1 tablet or 10 ml suspension once daily for 3 days.
Children (1-2 years): One half tablet or 5 ml suspension (200 mg) as a single dose. The tablet must be chewed, swallowed or crushed and mixed with food.
 

                    


Presentations:
1 tablet                   
                                               MRP           Retailer        Stockist

                                              12.00             9.60                8.64

 

 

 

 

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Structural Formula

 

Taj Values

Tablets

 

 
 
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