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Each tablet contains:
Composition:
Albendazole....................................................................400
mg
Indications :
ZENTIC-400 is indicated in the
treatment of hookworm (ancyclostoma,
necator), roundworm (ascaris),
threadworm (strongyloides), whipworm (trichuris),
tapeworm (taenia species), opisthorchis,
hydatid disease (echinococcus),neurocysticercosis,
mixed helminthic infestations.
Description:
Albendazole causes degenerative
alterations in the tegument and
intestinal cells of the worm by binding
to the colchicine-sensitive site of
tubulin, thus inhibiting its
polymerization or assembly into
microtubules. The loss of the
cytoplasmic microtubules leads to
impaired uptake of glucose by the larval
and adult stages of the susceptible
parasites, and depletes their glycogen
stores. Degenerative changes in the
endoplasmic reticulum, the mitochondria
of the germinal layer, and the
subsequent release of lysosomes result
in decreased production of adenosine
triphosphate (ATP), which is the energy
required for the survival of the
helminth. Due to diminished energy
production, the parasite is immobilized
and eventually dies.
Dosage : Adults and children over
two years: 1 tablet or 10 ml suspension
(400 mg) as a single dose. In
strongyloides or H. nana infestations, 1
tablet or 10 ml suspension once daily
for 3 days.
Children (1-2 years): One half tablet or 5 ml suspension (200
mg) as a single dose. The tablet must be
chewed, swallowed or crushed and mixed
with food.
Presentations:
1 tablet
MRP Retailer Stockist
12.00 9.60
8.64
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