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Each tablet contais :
Composition:
Artesunate
......................................................................50
mg
Indications:
Cerebral malaria, Chloroquine resistant
malaria, Plasmodium falciparum malaria,
Severe malaria.
Description:
Artesunate and its active metabolite
dihydroartemisinin are potent blood
schizonticides, active against the ring
stage of the parasite. It is effective
against P. falciparum resistant to all
other antimalarial drugs. It does not
have hypnozoiticidal activity. It
reduces gametocyte carriage rate.
The functional group responsible for
antimalarial activity of artesunate is
endoperoxide bond. Release of an active
oxygen species from this bond kills the
parasite if accumulated in the
erythrocytic cells.
It also suppresses the production or
activity of antioxidant enzymes in the
erythrocytes.
CONTRAINDICATIONS
The drug
is contraindicated in patients with
prior hypersensitivity to artesunate or
artemisinin derivatives, pyrimethamine
or sulphonamides. The drug is also
contraindicated in patients with severe
renal insufficiency, marked liver
parenchymal damage or blood dyscrasias,
patients with documented megaloblastic
anemia due to folate deficiency, infants
< 2 months of age, pregnancy and during
the nursing period.
Dosage :
Adults: Total oral dose of 600mg is
recommended which can be divided into
two tab. (100mg) bd on the first day
followed by 1 tab. (50mg) bd for next
four days.
Children: Half the adult dose in the
above manner.
Presentations :
MRP Retailer
Stockist
4 tablets
92.80 74.24
66.81
1 vial
169.95 135.96
122.36
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Taj Brands
