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Therapeutic Index

TRIP-MINI

Each kit contains:

Composition:
1 cap of Rifampicin..........................................................100 mg
1 Tab of Pyrazinamide.....................................................300 mg
1 Tab of  INH........................................................................50 mg

Indications :
Rifampicin, Ethambutol, Isoniazid, Pyrazinamide and Streptomycin are  used in medication and management of Tuberculosis.

Description:
Rifampicin inhibits DNA-dependent RNA polymerase in bacterial cells by binding its beta subunit, thus preventing transcription of messenger RNA (mRNA) and subsequent translation to proteins.
Pyrazinamide is a prodrug that stops the growth of Mycobacterium tuberculosis. M. tuberculosis has the enzyme pyrazinamidase which is only active at acidic pH. Pyrazinamidase converts pyrazinamide to the active form, pyrazinoic acid. Pyrazinoic acid inhibits the enzyme fatty acid synthetase I, which is required by the bacterium to synthesise fatty acids.
INH is thought to work through its effects on lipids (fats) and DNA within the tuberculosis bacterium.

Dosage :
Children : 10-15 mg /kg body wt. daily as single dose.

Presentations :             1kit                         
                                        
MRP          Retailer         Stockist
                                        
6.75              5.40                4.86

 

 

 

 

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