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Non-steroidal anti-inflammatory
drugs, usually abbreviated to NSAIDs or
NAIDs, are drugs with analgesic,
antipyretic (lowering an elevated body
temperature and relieving pain without
impairing consciousness) and, in higher
doses, with anti-inflammatory effects
(reducing inflammation).The most
prominent members of this group of drugs
are aspirin, ibuprofen, and naproxen
partly because they are available
over-the-counter in many areas.
Non-steroidal anti-inflammatory drugs,
usually abbreviated to NSAIDs or NAIDs,
are drugs with analgesic, antipyretic
(lowering an elevated body temperature
and relieving pain without impairing
consciousness) and, in higher doses,
with anti-inflammatory effects (reducing
inflammation).The most prominent members
of this group of drugs are aspirin,
ibuprofen, and naproxen partly because
they are available over-the-counter in
many areas.
Uses
NSAIDs are generally indicated for the
symptomatic relief of the following
conditions:
* Rheumatoid arthritis
* Osteoarthritis
* Inflammatory arthropathies (e.g.
ankylosing spondylitis, psoriatic
arthritis, Reiter's syndrome)
* Acute gout
* Dysmenorrhoea (menstrual pain)
* Metastatic bone pain
* Headache and migraine
* Postoperative pain
* Mild-to-moderate pain due to
inflammation and tissue injury
* Pyrexia (fever)
* Ileus
* Renal colic
* They are also given to neonate infants
whose ductus arteriosus is not closed
within 24 hours of birth
Examples
NSAIDs can be broadly classified based
on their chemical structure. NSAIDs
within a group will tend to have similar
characteristics and tolerability. There
is little difference in clinical
efficacy among the NSAIDs when used at
equivalent doses. Rather, differences
among compounds tended to be with
regards to dosing regimens (related to
the compound's elimination half-life),
route of administration, and
tolerability profile. Some more common
examples are given below.
* Celecoxib
* Etoricoxib
* Lumiracoxib
* Parecoxib
* Rofecoxib
* Valdecoxib
*Nimesulide (banned by several countries
for the potential risk of hepatotoxicity)
Others
* Ibuprofen
* Naproxen
* Diclofenac
* Licofelone |
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