Each film coated tablet contains :
Bupropion hydrochloride 150 mg (As
Nicotoxin is indicated for the treatment
of depression. It is also indicated as a
smoking cessation treatment.
Bupropion is a norepinephrine and
dopamine uptake inhibitor that has been
available for several years for the
treatment of depression and aiding
smokers to quit. Bupropion is an
antidepressant medication that affects
chemicals within the brain that nerves
use to send messages to each other.
These chemical messengers are called
neurotransmitters. The neurotransmitters
that are released by nerves are taken up
again by the nerves that release them
for reuse. (This is referred to as
reuptake.) Many experts believe that
depression is partly caused by an
imbalance among the amounts of
neurotransmitters that are released.
Bupropion is unrelated to other
antidepressants. It works by inhibiting
the reuptake of dopamine, serotonin, and
norepinephrine, an action which results
in more dopamine, serotonin, and
norepinephrine to transmit messages to
other nerves. Bupropion is unique in
that its major effect is on dopamine, an
effect which is not shared by the
selective serotonin reuptake inhibitors
or SSRIs (e.g. paroxetine, Paxil;
fluoxetine, Prozac; sertraline, Zoloft)
or the tricyclic antidepressants or TCAs
(e.g. amitriptyline, Elavil; imipramine,
Tofranil; desipramine, Norpramin).
Bupropion hcl is available as sustained
release bupropion SR.
Adults: Initially, 150 mg once daily in
the morning; titrate after no less than
4 days to 150 mg twice daily if needed.
The onset of antidepressant effects
takes 1–3 weeks, maximal effect may not
be noted for 4 weeks. The lowest dosage
that maintains remission is recommended.