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Each tablet contains:
Composition:
Nimesulide.......................................................................100
mg
Diclofenac
Sodium............................................................50
mg
Indications :
Namosid -D is indicated in
musculoskeletal disorders, dysmenorrhoea,
thrombophlebitis, postoperative pain,
ental and ENT inflammation.
Description:
Nimesulide is a nonsteroidal
anti-inflammatory drug (NSAID) of the
sulfonanilide class. Its
anti-inflammatory, analgesic and
antipyretic activities have been
demonstrated in several widely used
animal experimental models and in
numerous clinical trials. Nimesulide
only weakly inhibits prostaglandin
synthesis and appears to exert its
effects through various mechanisms. It
inhibits the release of oxidants from
activated neutrophils and has a
scavenging effect on hypochlorous acid
without affecting neutrophil function.
Nimesulide also decreases histamine
release from tissue mast cells and
inhibits the production of
platelet-activating factor by human
basophils. Furthermore, when added in
vitro to cultures of human articular
chondrocytes, nimesulide inhibits the
release of stromelysin and blocks
metalloproteinase activity.
Diclofenac may also be a unique member
of the NSAIDs. There is some evidence
that diclofenac inhibits the
lipooxygenase pathways, thus
reducing formation of the
leukotrienes (also
pro-inflammatory autacoids). There is
also speculation that diclofenac may
inhibit
phospholipase A2
as part of its mechanism of action.
These additional actions may explain the
high potency of diclofenac - it is the
most potent NSAID on a broad basis.
Dosage : Adults: 100 mg twice daily. Children: 5
mg/kg/day in 2-3 divided doses.
Presentations :
10 tablets
MRP Retailer
Stockist
24.50
19.60 17.64
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