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Each tablet contains:
Composition:
Nimesulide.........................................................................100
mg
Caffeine..................................................................................25mg
Chlorphenamine Maleate.....................................................4mg
Indications :
Nimesulide is indicated in
musculoskeletal disorders, dysmenorrhoea,
thrombophlebitis, postoperative pain,
dental and ENT inflammation.
Description:
Nimesulide is a nonsteroidal
anti-inflammatory drug (NSAID) of the
sulfonanilide class. Its
anti-inflammatory, analgesic and
antipyretic activities have been
demonstrated in several widely used
animal experimental models and in
numerous clinical trials. Nimesulide
only weakly inhibits prostaglandin
synthesis and appears to exert its
effects through various mechanisms. It
inhibits the release of oxidants from
activated neutrophils and has a
scavenging effect on hypochlorous acid
without affecting neutrophil function.
Nimesulide also decreases histamine
release from tissue mast cells and
inhibits the production of
platelet-activating factor by human
basophils. Furthermore, when added in
vitro to cultures of human articular
chondrocytes, nimesulide inhibits the
release of stromelysin and blocks
metalloproteinase activity.
Caffeine acts through multiple
mechanisms involving both action on
receptors and channels at the cell
membrane, as well as intracellular
action on Calcium and cAMP pathways. By
virtue of its
purine
structure it can act on some of the same
targets as adenosine related nucleosides
and nucleotides, like the cell surface
P1
GPCRs
for adenosine, as well as the
intracellular
Ryanodine receptor which is
the physiological target of cADPR (cyclic
ADP ribose), and
cAMP-phosphodiesterase (cAMP-PDE).
Although the action is
agonistic in some cases, it
is
antagonistic in others.
Physiologically, however, caffeine
action is unlikely due to increased RyR
opening, as it requires plasma
concentration above lethal dosage. The
action is most likely through adenosine
receptors
Dosage :
Adults: 100 mg twice daily. Children: 5
mg/kg/day in
2-3 divided doses.
Presentations :
10 tablets
MRP Retailer Stockist
26.50 21.20 19.08
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