Therapeutic Index

Each Tablet contains:
Lorazepam

COMPOSITION :
Loravan-1 Tablets
Each tablet contains Lorazepam BP 1 mg

Loravan-2 Tablets
Each tablet contains Lorazepam BP 2 mg

DESCRIPTION :

Lorazepam is an antianxiety agent belonging to the benzodiazepine group. Lorazepam is an agonist at benzodiazepine receptors in the CNS. It exerts a central depressant action on the CNS, which may be mediated by potentiating the inhibitory actions of GABA in the CNS. This will result in diminution of the ascending activating systems, particulary the serotoninergic and noradrenergic pathway from brain stem or the mid-brain to the cerebral cortex. It is a highly potent benzodiazepine with a binding affinity to the benzodiazepine recep- tor in brain considerably greater than the binding affinity of nitrazepam or diazepam.

INDICATIONS :

* Anxiety disorders
* Short-term relief of the symptoms of anxiety or anxiety associated with depressive symptoms
* Short-term treatment of insomnia associated with anxiety
* Premedication for general or dental surgery.

DOSAGE AND ADMINISTRATION :

Moderate and severe anxiety
Adults:
1-4 mg daily, in divided doses.

Insomnia associated with anxiety
Adults:
1-2 mg may be taken at bedtime

Premedication for surgery
Adults:
2-3 mg the night before operation and 2-4 mg one to two hours before operation. 1-2 mg may be administered one to two hours before dental treatment.

Elderly
The elderly may respond to lower doses and half the normal adult dose or less may be sufficient.

CONTRAINDICATIONS :

Hypersensitivity to benzodiazepines or to lorazepam or to its components, acute narrow-angle glaucoma, severe respiratory insufficiency, sleep apnoea syndrome, myasthenia gravis and severe hepatic insufficiency.

PACKAGING INFORMATION :

Loravan-1
Blister pack of 10 tablets

Loravan-2
Blister pack of 10 tablets

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