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Each 2ml contains:
Composition:
β Arteether
………….........................................……150
mg
Arachis Oil I.P.
.................................................................q.s.
Indications :
Artemotial is concentrated in
parasitized erythrocytes. The functional
group responsible for anti-malarial
activity of α / β arteether is
endoperoxide bridge. Iron from the
digested haemoglobin of the parasite's
victim reduces this bridge, releasing a
highly reactive free radical iron
species which causes lysis of the
parasitic cell.
Description:
β
arteether is a fast acting blood
schizonticidal agent for P. falciparum
malaria at the erythrocytic stage.
β arteether is concentrated in
parasitized erythrocytes. The functional
group responsible for antimalarial
activity of β arteether is endoperoxide
bridge. Iron from the digested
haemoglobin of the parasite's victim
reduces this bridge, releasing a highly
reactive free radical iron species which
causes lysis of the parasitic cell.
Lysis of parasitic cell membrane occurs.
Damage includes swelling and deformity
of food vacuoles membrane, nuclear
membrane, endoplasmic reticulum and
formation of autophagic vacuoles.
It is also proposed that β arteether
inhibits the protein synthesis and
alters the ribosomal organization and
endoplasmic reticulum.
CONTRAINDICATIONS
β arteether injection is contraindicated
in patients hypersensitive to
artemisinin derivatives
Dosage:
Adult: 150mg i.e. 1 ampoule of b
arteether once daily for 3 consecutive
days.
Children: 3mg/Kg per day administered by intramuscular
injection over a 3-day period.
Presentations:
MRP
Retailer Stockiest
99.00 79.20
71.28
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