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Each Injection contians:
Composition:
Melphalan
.........................................................50
mg
Indications:
Breast carcinoma, multiple myeloma,
advanced ovarian carcinoma, other
neoplasms in combination with surgery.
Malignant melanoma, polycythaemia vera.
Description:
Melphalan also known as L-phenylalanine
mustard, phenylalanine mustard, L-PAM or
L-sarcolysin, is a phenylalanine
derivative of nitrogen mustard.
Melphalan is a bifunctional alkylating
agent which is active against selective
human neoplastic diseases. It is known
chemically as 4-[bis(2-chloroethyl)
amino]-L-phenylalanine. The molecular
formula is C13H18Cl2N2O2 and the
molecular weight is 305.20. Melphalan is
the active L-isomer of the compound and
was first synthesized in 1953 by Bergel
and Stock; the D isomer, known as
medphalan, is less active against
certain animal tumors, and the dose
needed to produce effects on chromosomes
is larger than that required with the
L-isomer.
CONTRAINDICATIONS
ALPHEN should not be used in patients
whose disease has demonstrated a prior
resistance to this agent. Patients who
have demonstrated hypersensitivity to
melphalan should not be given the drug.
Dosage :
Adults: Multiple myeloma: Usual oral
dose 6mg/day. Maintenance dose 2mg/day.
Children: Multiple myeloma:
0.15mg/kg/day for 7 days. Maintenance
dose 0.05mg/kg/day when WBC/platelets
count are rising. Ovarian carcinoma:
0.2mg/kg/day for 5 days. Repeat course
after 4-5 weeks.
Presentations:
MRP Retailer Stockiest
1910.85 1528.68
1375.80
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